Description: This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson's Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center. Cutting-edge and authoritative, Clinical Trials in Parkinson's Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials. Series Preface...Dedication...Preface...Table of Contents...Contributing Authors... Part I Preclinical Models of Parkinson's Disease 1.Toxin-Based Rodent Models of Parkinson's DiseaseM. Angela Cenci Nilsson and Véronique Sgambato 2.Assessment of Non-Motor Symptoms in Rodent Models of Parkinson's DiseaseFrancesca Rossi, Manolo Carta, and Elisabetta Tronci 3.Genetic Models of Parkinson's Disease Philippe Kachidian and Paolo Gubellini Part II Clinical Trials for Motor Symptoms in Parkinson's Disease 4.A Review of Randomized Phase III Pharmacological Clinical Trials for Motor Symptoms in Parkinson's Disease Patients and Quality of Evidence RecommendationsMónica M. Kurtis, Carmen Rodriguez-Blazquez, and Isabel Pareés 5.Clinical Trials for Motor Complications in Parkinson's DiseaseTiago A. Mestre, Joaquim J. Ferreira, and Olivier Rascol 6. Clinical Trials for Gait Disorders in Parkinson's DiseaseZuzana Kosutzka, Urban M. Fietzek, and Peter Valkovic 7. Clinical Trials for Disease Modifying Agents in Parkinson's DiseaseOrlando Artavia and Lana Chahine 8. Value and Methods of Pharmacovigilance in the Monitoring of Drug Safety in Parkinson's DiseaseSantiago Perez-Lloret, James A.G. Crispo, Maria Veronica Rey, Donald Mattison, and Daniel Krewski Part III Clinical Trials for Non-Motor Symptoms in Parkinson's Disease 9. Clinical Trials for Cognitive Impairment and Dementia in Parkinson's DiseaseBrandon Barton 10. Clinical Trials for Depression, Anxiety, Fatigue, and Apathy in Parkinson's DiseaseMatej Skorvanek and Marek Balaz 11. Clinical Trials for Sleep Disorders and Daytime Somnolence in Parkinson's DiseaseMarissa N. Dean and Amy W. Amara 12. Clinical Trials on Management of Pain in Parkinson's DiseaseAzman Aris, Raquel Taddei, Alexandra Rizos, Anna Sauerbier, and K. Ray Chaudhuri 13. Clinical Trials for Orthostatic Hypotension in Parkinson's Disease and Other Synucleinopathies Jose-Alberto Palma and Horacio Kaufmann 14. Clinical Trials for Erectile Dysfunction in Parkinson's DiseaseShen-Yang Lim, Ai Huey Tan, and Mathis Grossmann 15. Clinical Trials for Constipation in Parkinson's DiseasePatricio Millar Vernetti Subject Index List...
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EAN: 9781071609149
UPC: 9781071609149
ISBN: 9781071609149
MPN: N/A
Item Length: 25.4 cm
Number of Pages: 396 Pages
Publication Name: Clinical Trials in Parkinson's Disease
Language: English
Publisher: Springer-Verlag New York Inc.
Item Height: 254 mm
Subject: Medicine, Biology
Publication Year: 2021
Type: Textbook
Item Weight: 780 g
Author: Santiago Perez-Lloret
Item Width: 178 mm
Format: Paperback
